Variation of diastereoisomeric pyrrolizidine alkaloids in Pleurothallis (Orchidaceae).

Qualitative and Quantitative Determination of Pyrrolizidine Alkaloids of Wheat and Flour Contaminated with Senecio in Mazandaran Province Farms

The Pyrrolizidine Alkaloids (PAs) are a group of chemicals found in a variety of plant species throughout the world. These toxic alkaloids are distributed mainly in Senecio (Compositae), Crotalaria (Legominosae) and Heliotropium (Boraginaceae) species. Plants containing these alkaloids cause significant mammalian morbidity and mortality, especially in humans. Upon ingestion, metabolic activatio...

Title: Pyrrolizidine alkaloid variation in Jacobaea hybrids : influence on resistance against generalist and specialist insect herbivores

Qualitative and Quantitative Determination of Pyrrolizidine Alkaloids of Wheat and Flour Contaminated with Senecio in Mazandaran Province Farms

The Pyrrolizidine Alkaloids (PAs) are a group of chemicals found in a variety of plant species throughout the world. These toxic alkaloids are distributed mainly in Senecio (Compositae), Crotalaria (Legominosae) and Heliotropium (Boraginaceae) species. Plants containing these alkaloids cause significant mammalian morbidity and mortality, especially in humans. Upon ingestion, metabolic activatio...

Genotoxic Pyrrolizidine Alkaloids — Mechanisms Leading to DNA Adduct Formation and Tumorigenicity

Plants that contain pyrrolizidine alkaloids are widely distributed in the world. Although pyrrolizidine alkaloids have been shown to be genotoxic and tumorigenic in experimental animals, the mechanisms of actions have not been fully understood. The results of our recent mechanistic studies suggest that pyrrolizidine alkaloids induce tumors via a genotoxic mechanism mediated by 6,7-dihydro-7-hyd...

Qualitative and Quantitative Study of Pyrrolizidine Alkaloids in Medicinal Plants Sold in Herb Shops

 Background and purpose: Pyrrolizidine alkaloids (PAs) are a group of chemical compounds that are seen as secondary metabolites in different plant families. These compounds can cause liver, kidney, and lung damages and their presence in various herbal products increases the risk of injury. This study aimed at performing qualitative and quantitative evaluation of pyrrolizidine alkaloids in medic...